Meningitis

Pathological changes found in the envelopes of convex and basal surfaces of the brain. Purulent and fibrinous-purulent exudation covering the brain blue-green cap. Polinuklearnye infiltration along the vessels penetrate the brain substance. Developed edema and hyperemia of cerebral substance. Similar changes observed in the spinal cord. With timely treatment of inflammatory process is initiated in the torrent of shells, subjected to exudation complete resorption. In running a case and irrational treatment of sclerosis may develop cerebral shells, imperforated mezhzheludochkovogo hole pair and the pair of lateral openings of the fourth ventricle, connecting the fourth ventricle with a large tank of brain - that leads to likvorodinamiki and development of hydrocephalus.

Morphological changes in the meningokokkemii match infectious-toxic shock syndrome with a strong trombogemorragicheskim. In line with observed microcirculatory plazmorragiya, hyperemia, stasis, revealed fibrinous thrombus fibrinoidny and necrosis of vascular walls. For meningokoktsemii especially characterized by multiple hemorrhages in the skin, bilateral massive hemorrhage in the adrenal glands with the development of acute adrenal insufficiency (Waterhouse-Frideriksena syndrome) and acute edema of the brain. In the kidney indicate dystrophic and necrotic changes in epithelial canals. In the envelopes of the brain causing meningococcus initially serous-purulent inflammation, but by the end of the day becomes purulent exudation. Purulent exudation located predominantly in the basal surface of the brain. In addition to inflammatory changes in the environment of the brain substance and there expressed vascular disorders, plethora, stasis, thrombosis, hemorrhage. For 5-6-th day of illness purulent exudation organized, but with a favorable clinical course, it further exposed to enzyme solution.